Defining clinical remission and clinically inactive disease in juvenile systemic lupus erythematosus (jSLE)
نویسندگان
چکیده
Defining clinical remission and clinically inactive disease in juvenile systemic lupus erythematosus (jSLE) Rina Mina, Laura Schanberg, Anne B Eberhard, Marisa Klein–Gitelman, Gloria Higgins, Karen Onel, Nora G Singer, Kathleen O’ Neil, Lori Tucker, Deborah Levy, Wajeeha Yousaf, Shannen Nelson, Michael Beresford, Ruben Cuttica, Graciela Espada, Angelo Ravelli, Alberto Martini, Edward Giannini, Hermine I Brunner
منابع مشابه
Diagnostic performance and clinical associations of antibodies to the chromatin antigenic system in juvenile systemic lupus erythematosus.
OBJECTIVES To determine the frequency of antibodies to chromatin components in juvenile systemic lupus erythematosus (JSLE), and to correlate the presence of these autoantibodies with clinical manifestations and disease activity. METHODS Anti-chromatin (anti-CHR), anti-nucleosome core particle (anti-NCS) and anti-dsDNA antibodies were measured in 175 individuals, including 37 patients with ac...
متن کاملOral Ulcers in Juvenile-Onset Systemic Lupus Erythematosus: A Review of the Literature
Oral ulcers are the most common mucosal sign in juvenile-onset systemic lupus erythematosus (JSLE). The ulcers are one of the key clinical features; however, the terminology of oral ulcers, especially in JSLE patients, is often vague and ill-defined. In fact, there are several clinical manifestations of oral ulcers in JSLE, and some lesions occur when the disease is active, indicating that earl...
متن کاملUrinary VCAM-1 as a biomarker of lupus nephritis disease activity
Introduction Up to 80% of children with Juvenile Systemic Lupus Erythematosus (JSLE) develop lupus nephritis (LN) (1), with the 5-year renal survival rate varying between 44-94% (2-4). Conventional markers of JSLE disease activity fail to adequately predict impending LN flares (5), with significant renal involvement (class III, IV or V LN) known to occur with low level proteinuria (6). Cross-se...
متن کاملScaly Ear Rash as the Herald of a Young Girl with Juvenile Systemic Lupus Erythematosus
Juvenile systemic lupus erythematosus (JSLE) is an autoimmune-mediated multiorgan disease. The cutaneous manifestation is one of the most common initial presentations in JSLE. A typical lesion is a facial malar rash, but a patient may sometimes present with nonclassical lesions. Herein, we report two cases of JSLE with similar persistent scaly ear rashes as the heralding cutaneous symptom prece...
متن کاملAnticardiolipin Antibodies in Juvenile Rheumatoid Arthritis and Systemic Lupus Erythematosus
Background: Antiphospholipid antibody syndrome (APS) can either occur as a primary syndrome or associated with other autoimmune diseases such as systemic lupus erythematosus (SLE). Anticardiolipin antibody (aCL) of IgG and/or IgM isotype in blood, measured by a standardized ELISA is the most acceptable laboratory criteria. APS IgG isotype, particularly IgG2 subclass is more strongly associated ...
متن کامل